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Ingredients: A proprietary blend of chanca piedra whole herb (Phyllanthus niruri), Bellaco caspi bark (Himatanthus sucuuba), tamamuri bark (Brosimum acutifolium), matico leaf (Piper aduncum), huacapu bark (Minquartia guianensis), and ajos sacha bark & leaf (Mansoa alliacea)
Suggested Use: As nutritional supplement. Take 2-3 capsules twice daily on an empty stomach or as directed by a health care practitioner.
Contraindications: None reported.
Drug Interactions: None reported.
Other Practitioner Observations: The botanicals contained in this formula have demonstrated antimicorbial properties. Therefore, it's advisable to supplement the diet with probiotics or digestive enzymes when this formula is taken for more than 30 days.
References
Chanca Piedra (Phyllanthus niruri)
Subeki, S., et al. "Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri." J. Nat. Prod. 2005; 68(4): 537-9.
Mazumder, A., et al. "Antimicrobial potentiality of Phyllanthus amarus against drug resistant pathogens." Nat. Prod. Res. 2006; 20(4): 323-6.
Okigbo, R. N., et al. "Antimicrobial effects of Piper guineense 'Uziza' and Phyllantus amarus 'Ebe-benizo' on Candida albicans and Streptococcus faecalis." Acta Microbiol. Immunol. Hung. 2007 Dec; 54(4): 353-66.
Farouk, A., et al. "Antimicrobial activity of certain Sudanese plants used in folkloric medicine. Screening for antibacterial activity (I)." Fitoterapia 1983; 54(1): 3-7.
Kloucek, P., et al. "Antibacterial screening of some Peruvian medicinal plants used in Calleria District." J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.
Bellaco Caspi (Himatanthus sucuuba, lancifolius)
Souza, W., et al. "Antimicrobial activity of alkaloidal fraction from barks of Himatanthus lancifolius." Fitoterapia. 2004 Dec; 75(7-8): 750-3.
Tundis, R., et al. "Biological and pharmacological activities of iridoids: recent developments." Mini. Rev. Med. Chem. 2008; 8(4): 399-420.
Little, J., et al. "Plumericin; an antimicrobial agent from Plumeria multiflora." Arch. Biochem. 1951; 30(2): 445-52.
Persinos-Perdue, G., et al. " South American plants. III. Isolation of fulvoplumierin from Himatanthus sucuuba (Apocynaceae). J. Pharm. Sci. 1978; 67: 1322.
Wood, C. A., et al. "A bioactive spirolactone iridoid and triterpenoids from Himatanthus sucuuba." Chem. Pharm. Bull. 2001; 49(11): 1477-1478.
De Silva, J. R., et al. "Triterpenic esters from Himatanthus sucuuba (Spruce) Woodson." Quimica Nova 1998; 21(6): 702-704.
Castillo, D., et al. Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae)." J. Ethnopharmacol. 2007 Jun; 112(2): 410-4.
Tamamuri (Brosimum acutifolium)
Tundis, R., et al. "Biological and pharmacological activities of iridoids: recent developments." Mini. Rev. Med. Chem. 2008 Apr;8(4):399-420.
Herforth, A., et al. "Amazonian Women's Medicine: Treatments for Mycoses." Poster: Society for Economic Botany 2002 vol 56(4).
Herforth, A., et al. " Antifungal plants of the Peruvian Amazon: A survey of ethnomedical uses and biological activity." Cornel University Publication 2002
Takashima, J., et al. "Brosimacutins J-M, four new flavonoids from Brosimum acutifolium and their cytotoxic activity." Planta Med. 2005; 71(7): 654-8.
Takashima J, et al. "Mururins A-C, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity. Planta Med. 2002; 68(7): 621-5.
Matico (Piper aduncum)
Batista, J.M., Jr., et al. "Natural chromenes and chromene derivatives as potential anti-trypanosomal agents." Biol. Pharm. Bull. 2008 Mar;31(3):538-40.
Braga, F. G., et al. "Antileishmanial and antifungal activity of plants used in traditional medicine in Brazil." J. Ethnopharmacol. 2007 May 4;111 (2):396-402.
Orjala, J., et al. "New monoterpene-substituted dihydrochalcones from Piper aduncum." Helv. Chim. Acta 1993; 76(4): 1481-1488.
Kloucek, P., et al. "Antibacterial screening of some Peruvian medicinal plants used in Calleria district." J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.
Lemos, T. L. G., et al. "Antimicrobial activity of essential oils of Brazilian plants." Phytother. Res. 1990; 4(2): 82-84.
Lentz, D. L., et al. "Antimicrobial properties of Honduran medicinal plants." J. Ethnopharmacol. 1998; 63(3): 253-263.
Trillini, B., et al. "Chemical composition and antimicrobial activity of essential oil of Piper angustifolium." Planta Med. 1996; 62(4): 372-373.
Orjala, J., et al. "Cytotoxic and antibacterial dihydrochalcones from Piper aduncum." J. Nat. Prod. 1994; 57(1): 18-26.
Orjala, J., et al. "Three new prenylated benzoic acid derivatives and molluscicidal sesquiterpenoids from Piper aduncum leaves." Planta Med. Suppl. 1992; 58(1) A714-.
Orjala, J., et al. "Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves." Planta Med. 1993; 59(6): 546-551.
Orjala, J., et al. "Aduncamide, a cytotoxic and antibacterial beta-phenylethylamine-derived amide from Piper aduncum." Nat. Prod. Lett. 1993; 2(3): 231-236.
Huacapu (Minquartia guianensis)
Rashid, M. A., et al. "Absolute stereochemistry and anti-HIV activity of minquartynoic acid, a polyacetylene from Ochanostachys amentacea." Nat. Prod. Lett. 2001; 15(1): 21-26 . El-Seedi, H. R., et al. "Triterpenes, lichexanthone and an acetylenic acid from Minquartia guianensis." Phytochemistry. 1994; 35 (5): 1297-1299. Jovel, E. M., et al. "An ethnobotanical study of the traditional medicine of the Mestizo people of Suni Mirano, Loreto, Peru." J. Ethnopharmacol. 1996; 53: 149-156. Rasmussem, H. B., et al. "Absolute configuration and antiprotozoal activity of minquartynoic acid." J. Nat. Prod. 2000; 63(9): 1295-1296.
Ajos Sach (Mansoa alliacea, Adenocaymma alliaceum)
Canapaty, S., et al. "Composition of leaf oil from Adenocalymma alliaceum and its antimicrobial activity." Indian Perfumer 2004; 48(3): 323-329.
Rao, A. M., et al. "Antimicrobial activity of the leaf extract of Adenocalymma alliaceum." Indian Drugs. 1985: 22(7): 364-365.
Silva, T. M., et al. "Molluscicidal activities of six species of Bignoniaceae from north-eastern Brazil, as measured against Biomphalaria glabrata under laboratory conditions." Ann. Trop. Med. Parasitol. 2007 Jun; 101(4):359-65.
Rana, B. K., et al. "Antifungal activity of an aqueous extract of leaves of garlic creeper (Adenocaymma alliaceum Miers.)." Pharmaceutical Biol. 1999; 37(1):. 13-16.
Singh, U. P., et al. "A rapid method for detecting fungi-toxic substances." World Journal of Microbiology and Biotechnology. 1996; 12(3): 301-302.
Khurana, S., et al. "Effect of plant extracts on the activity of three papaya viruses." J. Gen. Appl. Microbiol. 1970; 16: 225-230.
Ushamalini, C., et al. "Management of charcoal rot of cowpea using biocontrol agents and plant products." Indian Phytopathol. 1997; 50(4): 504-507.
Ushamalini, C., et al. "Suppression of charcoal rot and wilt pathogens of cowpea by botanicals." Plant Disease Research 1997; 12(2): 113-117.
WARNINGS: Information, statements and products on this website have not been evaluated by the FDA and are not intended to diagnose, mitigate, treat, cure, or prevent any disease or health condition. The natural properties of the botanicals are only referred to their common uses among folk and herbal traditions. Our products are not intended to diagnose, cure, or prevent any disease as well. It's not meant to give any suggestion of diagnosis or disesase treatment. Please see a doctor when needed.