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Ingredients: A proprietary blend of pau d'arco, tayuya, manacá, mulungu, amor seco, and iporuru.
Suggested Use: As a nutritional supplement, take 2-3 capsules every 4-6 hours as needed.
Contraindications:
- Do not use during pregnancy or while breast-feeding.
- Some studies have documented that manacá has anticoagulant properties. Therefore, it is recommended to individuals with blood disorders such as hemophilia a closer monitoring.
Drug Interactions: May potentiate anticoagulants, MAO-inhibitors and antihypertensive medications.
Other Practitioner Observations:
- Manacá contains salicylate. People with an allergy or sensitivity to salicylates or aspirin may be sensitive to this formula.
- This formula may cause drowsiness at higher dosages. If this occurs, reduce the amount used.
- Plants in this formula may reduce blood pressure. It is recommended to those with low blood pressure a closer monitoring.
- Brain Support, a proprietary blend of Rainforest botanicals (calaguala included) used by shamans to support brain functions
- MSM, a natural occuring molecule that's believed to have several functions in the body (such as to detoxify, against allergies, inflammations, and aches)
References
Pau d'arco (Tabebuia impetiginosa)
de Miranda, F. G., et al. “Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract.” BMC. Pharmacol. 2001; 1(1): 6.
Awale, S., et al. ”Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil.” Chem. Pharm. Bull. 2005; 53(6): 710-3.
Oga, S., et al. “Toxicidade e atividade anti-inflamatoria de Tabebuia avellanedae Lorentz (‘Ipe Roxo’).” Rev. Fac. Farm. Bioquim. 1969; 7: 4.
Tayuya (Cayaponia tayuya)
Escandell, J. M., et al. “Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant- induced arthritis.” Eur. J. Pharmacol. 2006 Jan 26;
Recio, M. C., et al. “Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.” Planta Med. 2004; 70(5): 414-20.
Himeno, E., et al. “Structures of cayaponosides A, B, C and D, glucosides of new nor-cucurbitacins in the roots of Cayaponia tayuya.” Chem. Pharm. Bull. (Tokyo) 1992; 40(10): 2885–87.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom—I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86 (Suppl. 2): 203–5.
Rios, J. L., et al. “A study of the anti-inflammatory activity of Cayaponia tayuya root.” Fitoterapia 1990; 61(3):275–78.
Faria, M. R. and E. P. Schenkel. “Caracterizacao de cucurbitacinas em especies vegetais cohecidas popularmente como taiuiá.” Ciencia e Cultura (São Paulo) 1987; 39: 970–73.
Bauer, R., et al. “Cucurbitacins and flavone C-glycosides from Cayaponia tayuya.” Phytochemisty. 1984: 1587–91.
Manacá (Brunfelsia uniflora)
Rollinger, J. M., et al. “Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products.” J. Med. Chem. 2004 Dec 2; 47(25): 6248-54.
Park, J. H., et al. “Antiinflammatory activity of Synurus deltoides.” Phytother. Res. 2004; 18(11): 930-3.
Kim, H. J., et al. “Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells.” Fitoterapia. 2004 Jun; 75(3-4): 261-6.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom–I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86: 203–5.
Iyer, R. P., et al. “Brunfelsia hopeana I: Hippocratic screening and antiinflammatory evaluation." Lloydia. 1977; 40(4): 356–60.
de Costa, A. O. “A pharmacologic study of manacá (Brunfelsia hopeana)." Bol. Assoc. Bras. Pharm. 1933; 14: 295–99.
Mulungu (Erythrina mulungu)
Marchioro, M., et al. “Anti-nociceptive activity of the aqueous extract of Erythrina velutina leaves.” Fitoterapia. 2005 Dec; 76(7-8): 637-42.
Chaddock, J. A., et al. “Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.” Mov. Disord. 2004 Mar; 19 Suppl 8: S42-7.
Weber, D., et al. “Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli.” J. Antibiot. 2004; 57(9): 559-63.
Vasconcelos, S. M., et al. “Antinociceptive activities of the hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice.” Biol. Pharm. Bull. 2003; 26(7): 946-9.
Njamen, D., et al. “Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii.”
Eur. J. Pharmacol. 2003 May; 468(1): 67-74.
Duggan, M. J., et al. “Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina crista-galli lectin.” J. Biol. Chem. 2002 Sep; 277(38): 34846-52.
Amor Seco (Desmodium adscendens)
N’Gouemo, P., et al. “Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents.” J. Ethnopharmacol. 1996; 52(2): 77–83.
McManus, O. B., et al. “An activator of calcium-dependent potassium channels isolated from a medicinal herb.” Biochemistry 1993; 32(24): 6128–33.
Addy, M. E., et al. “Some secondary plant metabolites in Desmodium adscendens and their effects on arachidonic acid metabolism.” Prostaglandins Leukotrienes Essent. Fatty Acids 1992; 47(1): 85–91.
Boye, G. and O. Ampopo. “Plants and traditional medicine in Ghana.” Economic and Medicinal Plant Research 4 1990. Devon, England: Academic Press Ltd.: 33–4.
Addy, M. E., et al. “Effect of Desmodium adscendens fraction 3 on contractions of respiratory smooth muscle.” J. Ethnopharmacol. 1990; 29(3): 325–35.
Iporuru (Alchornea castaneifolia)
Manga, H.M., et al. “In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae).” J. Ethnopharmacol. 2004 Jun; 92(2-3): 209-14.
Osadebe, P. O., et al. “Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia leaves.” J. Ethnopharmacol. 2003 Nov; 89(1):19-24.
Tona, L., et al. “Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo.” Phytomedicine. 2000 Mar; 7(1): 31-8.
Dunstan, C. A., et al. “Evaluation of some Samoan and Peruvian medicinal plants by prostaglandin biosynthesis and rat ear oedema assays.” J. Ethnopharmacol. 1997; 57: 35–56.
Ogungbamila, F. O., et al. “Smooth muscle–relaxing flavonoids from Alchornea cordifolia.” Acta Pharm. Nord. 1990; 2(6): 421–22.
Persinos-Perdue, G., et al. “Evaluation of Peruvian folk medicine by the natural products research laboratories.” Abstra. Joint Meeting American Society of Pharmacognosy and Society for Economic Botany, Boston, 1981; (5) 13
WARNINGS: Information, statements and products on this website have not been evaluated by the FDA and are not intended to diagnose, mitigate, treat, cure, or prevent any disease or health condition. The natural properties of the botanicals are only referred to their common uses among folk and herbal traditions. Our products are not intended to diagnose, cure, or prevent any disease as well. It's not meant to give any suggestion of diagnosis or disesase treatment. Please see a doctor when needed.