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Ingredients: 100% pure natural blend of picão preto, boldo, carqueja, jurubeba, espinheira santa, guacatonga, and gervâo.
Suggested Use: As nutritional supplement. Take 2-3 capsules with each meal or as directed by a healthcare professional.
Contraindications:
- Not to be used during pregnancy, while breast-feeding or while seeking to become pregnant.
- Several plants in this formula may have anticoagulant activities or contain naturally-occurring coumarin. The formula is contraindicated for persons with bleeding disorders such as hemophilia.
- Several plants in this formula may reduce blood pressure. Those with low blood pressure should be monitored for this possible effect.
Drug Interactions: May potentiate anticoagulant and antihypertensive medications.
Other Practitioner Observations: Several ingredients in this formula have demonstrated antacid actions; therefore, this formula should not be used by persons with low stomach acid.
Also Suggested:
- Carqueja Concentrated Extract, extract form the plant traditionally used in Brazil as a folk remedy against gallbladder disorders
- Guacatonga, from the Amazon an herb usd as folk remedy for stomach disorders (ulcers, acid reflux, indigestion, dyspepsia, stomachache), skin rashes and wounds, and to purify the blood
References
Picão Preto (Bidens pilosa)
Lans, C. "Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine." J. Ethnobiol. Ethnomedicine. 2007 Jan; 3(1): 3.
Atta, A. H., et al. "Evaluation of some medicinal plant extracts for antidiarrhoeal activity." Phytother. Res. 2005 Jun; 19(6): 481-5.
Tan, P. V., et al. “Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats.” J. Ethnopharmacol. 2000; 73(3): 415–21.
Alvarez, A., et al. “Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip.” J. Ethnopharmacol. 1999; 67(3): 333–40.
Avalos, A. A., et al. “Influence of extracts from leaves and stem of Bidens pilosa on experimental ulcerogenesis in rats.” Rev. Cubana Farm. 1984; 18(2): 143–50.
Chin, H. W., et al. “The hepatoprotective effects of Taiwan folk medicine ‘ham-hong-chho’ in rats.” Am. J. Chin. Med. 1996; 24(3–4): 231–40.
Khan, M. R., et al. “Anti-microbial activity of Bidens pilosa, Bischofia javanica, Elmerillia papuana and Sigesbekia orientalis.” Fitoterapia. 2001; 72(6): 662–65.
Chariandy, C. M., et al. “Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties.” J. Ethnopharmacol. 1999; 64(3): 265–70.
Rabe, T. “Antibacterial activity of South African plants used for medicinal purposes.” J. Ethnopharmacol. 1997; 56(1): 81–7.
van Puyvelde, L., et al. “In vitro inhibition of mycobacteria by Rwandese medicinal plants.” Phytother. Res. 1994; 8(2): 65–9.
Boldo (Peumus boldus)
O'brien, P., et al. "Boldine and its antioxidant or health-promoting properties." Chem. Biol. Interact. 2006 Jan; 159(1): 1-17.
Reiniger, I. W., et al. “Boldine action against the stannous chloride effect.” J. Ethnopharmacol. 1999 Dec; 68(1-3): 345-8.
Gotteland, M., et al. “Protective effect of boldine in experimental colitis.” Planta Med. 1997; 63(4): 311–15.
Gotteland, M., et al. “Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers.” Rev. Med. Chil. 1995; 123(8): 955–60.
Kang, J. J., et al. “Studies on neuromuscular blockade by boldine in the mouse phrenic nerve diaphragm.” Planta Med. 1999; 65(2): 178–79.
Kang, J. J., et al. “Effects of boldine on mouse diaphragm and sarcoplasmic reticulum vesicles isolated from skeletal muscle.” Planta Med. 1998; 64(1): 18–21.
Backhouse, N., et al. “Anti-inflammatory and antipyretic effects of boldine.” Agents Actions 1994; 42(3–4): 114–17.
Carqueja (Baccharis genistelloides, trimera)
Betoni, J., et al. "Synergism between plant extract and antimicrobial drugs used on Staphylococcus aureus diseases." Mem. Inst. Oswaldo Cruz. 2006 Jun; 101(4): 387-90.
Gonzales, E., et al. “Gastric cytoprotection of Bolivian medicinal plants.” J. Ethnopharmacol. 2000; 70(3): 329–33.
Melo, S. F., et al. “Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts
against the stannous chloride oxidative damage in Escherichia coli.” Mutat. Res. 2001 Sep; 496(1-2): 33-8.
Gamberini, M. T., et al. “Açoes antiúlcera e antiácida do extracto aquoso e das fraçoes da Baccharis trimera.” Anais XII Simposio de Plantas Medicinais do Brasil. UFP: Curitiba, Paraná, 15–17 September 1992.
Sousa, B., et al., “Avaliaçao da atividade antiulcera do extrato bruto e fraçoes de Baccharis trimera.” Anais XII Simposio de Plantas Medicinais do Brasil. UFP: Curitiba, Paraná, 15–17 September 1992.
Gamberini, M. T., et al. “Inhibition of gastric secretion by a water extract from Baccharis triptera. Mart.” Mem. Inst. Oswaldo Cruz. 1991; 86(Suppl. 2): 137-9.
Abad, M. J., et al. “Anti-inflammatory activity of four Bolivian Baccharis species (Compositae).” J. Ethnopharmacol. 2006 Feb; 103(3): 338-44.
Hnatyszyn, O., et al. “Argentinian plant extracts with relaxant effect on the smooth muscle of the corpus cavernosum of guinea pig.” Phytomedicine. 2003 Nov; 10(8): 669-74.
Torres, L. M., et al. “Diterpene from Baccharis trimera with a relaxant effect on rat vascular smooth muscle.” Phytochemistry. 2000 Nov; 55(6): 617-9.
Gene, R. M., et al. “Anti-inflammatory and analgesic activity of Baccharis trimera: Identification of its active constituents.” Planta. Med. 1996; 62(3): 232–5.
Gene, R. M., et al. “Anti-inflammatory effect of aqueous extracts of three species of the genus Baccharis.” Planta Med. 1992 Dec; 58(6): 565-6.
Jurubeba (Solanum paniculatum)
Botion, L. M., et al. “Effects of the Brazilian phytopharmaceutical product Jerobina® on lipid metabolism and intestinal tonus.” J. Ethnopharmacol. 2005 Nov; 102(2): 137-42.
Braga, F. T., et al. Jurubeba. Centro Universitário de Lavras, Lavras-MG Brazil, 2002.
Mesia-Vela, S., et al. “Solanum paniculatum L. (Jurubeba): Potent inhibitor of gastric acid secretion in mice.” Phytomedicine 2002; 9(6): 508–14.
Espinheira Santa (Maytenus ilicifolia, aquifolium)
Cipriani, T. R., et al. "A polysaccharide from a tea (infusion) of Maytenus ilicifolia leaves with anti-ulcer protective effects." J. Nat. Prod. 2006; 69(7):1018-21.
Ferreira, P. M., et al. “A lyophilized aqueous extract of Maytenus ilicifolia leaves inhibits histamine-mediated acid secretion in isolated frog gastric mucosa.” Planta Med. 2004 Jun; 219(2): 319-24.
Jorge, R. M., et al. “Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia.” J. Ethnopharmacol. 2004 Sep; 94(1): 93-100.
Tabach, R., et al. “Evaluation of the anti-ulcerogenic activity of a dry extract of Maytenus ilicifolia Martius ex. Reiss produced by a jet spouted bed dryer.” Pharmazie. 2003 Aug; 58(8): 573-6.
Leite, J. P., et al. “Isolation and HPLC quantitative analysis of flavonoid glycosides from Brazilian beverages (Maytenus ilicifolia and M. aquifolium).” J. Agric. Food Chem. 2001; 49(8): 3796-801.
Melo, S. F., et al. “Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts
against the stannous chloride oxidative damage in Escherichia coli.” Mutat. Res. 2001 Sep; 496(1-2): 33-8.
Queiroga, C. L., et al. “Evaluation of the antiulcerogenic activity of friedelan-3beta-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae).”J. Ethnopharmacol. 2000 Oct; 72(3): 465-8.
Souza-Formigoni, M. L., et al. “Antiulcerogenic effects of two Maytenus species in laboratory animals.” J. Ethnopharmacol. August 1991.
Guacatonga (Casearia sylvestris)
Esteves, I., et al. “Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw.” J. Ethnopharmacol. 2005 Oct; 101(1-3): 191-6.
Sertie, J. A., et al. “Antiulcer activity of the crude extract from the leaves of Casearia slyvestris.” Pharmaceutical Biol. 2000; 38(2): 112–19.
Basile, A. C., et al. “Pharmacological assay of Casearia sylvestris. I: Preventive anti-ulcer activity and toxicity of the leaf crude extract.” J. Ethnopharmacol. 1990; 30(2): 185–97.
Gervâo (Stachytarpheta jamaicensis, cayennensis)
Lee, J. H., et al. "The effect of acteoside on histamine release and arachidonic acid release in RBL-2H3 mast cells." Arch. Pharm. Res. 2006 Jun; 29(6): 508-13.
Penido, C., et al. “Anti-inflammatory and anti-ulcerogenic properties of Stachytarpheta cayennensis (L.C. Rich) Vahl.” J. Ethnopharmacol. 2006 Mar; 104(1-2): 225-33.
Mesia-Vela, S., et al. “Pharmacological study of Stachytarpheta cayennensis Vahl in rodents.” Phytomedicine. 2004; 11(7-8): 616-24.
Vela, S. M., et al. “Inhibition of gastric acid secretion by the aqueous extract and purified extracts of Stachytarpheta cayennensis.” Planta Med. 1997; 63(1): 36–9.
Almeida, C. E., et al. “Analysis of antidiarrhoeic effect of plants used in popular medicine.” Rev. Saude. Publica. 1995; 29(6): 428–33.
WARNINGS: The statements given in these pages have an informative aim and are drawned on international publications. The natural properties of the botanicals are only referred to their common uses among folk and herbal traditions. Our products are not intended to diagnose, cure, or prevent any disease as well. It's not meant to give any suggestion of diagnosis or disesase treatment. Please see a doctor when needed.