Sarsaparilla

(Smilax sp.)

Family: Smilacaceae
Genus: Smilax
Species: officinalis, aristolochiaefolia, glabra, febrifuga, ornata, regelii, japicanga
Synonyms: Smilax medica
Common Names: Sarsaparilla, salsaparrilha, khao yen, saparna, smilace, smilax, zarzaparilla, jupicanga
Phytochemicals: Aluminum, Ash, Beta-sitosterol, Calcium, Cetyl-alcohol , Chromium, Cobalt, EO, Epsilon-sitosterol, Glucose, Iron, Magnesium, Manganese, Parigenin, Parillin, Phosphorus, Pollinastanol, Potassium, Resin, Saponin, Sarasaponin, Sarsaparilloside, Sarsaponin, Sarsasapogenin, Selenium, Silicon, Sitosterol-d-glucoside, Smilagenin, Smilasaponin, Stigmasterol, Tin, Zinc
Part Used: Root

HERBAL PROPERTIES AND ACTIONS

Main Actions: detoxifies organs cleanses blood aids absorption kills bacteria stimulates digestion increases urination protects liver promotes perspiration

Other Actions: relieves pain kills fungi reduces inflammation kills germs reduces fever immunomodulator fights free radicals relieves rheumatism

Standard Dosage: Root. Decoction: 1/2 to 1 cup 2-3 times daily; Capsules: 1-2 g twice daily; Tincture: 2-3 ml twice daily

Sarsaparilla is a brambled, woody vine that grows up to 50 m long, with paired tendrils for climbing (often high into the rainforest canopy). It is native to South America, Jamaica, the Caribbean, Mexico, Honduras, and the West Indies. The name sarsaparilla or zarzaparilla comes from the Spanish word "zarza" (bramble or bush), "parra" (vine), and "illa" (small)—a small, brambled vine.

The stems of many Smilax species are covered with prickles and, sometimes, these vines are cultivated to form impenetrable thickets (which are called catbriers or greenbriers). The root, used for medicinal purposes, is long and tuberous—spreading 6–8 feet—and is odorless and fairly tasteless. Many species of Smilax around the world share the name sarsaparilla; these are very similar in appearance, uses, and even chemical structure. These include S. officinalis, S. japicanga, and S. febrifuga from South America (Brazil, Ecuador and Colombia); S. regelii, S. aristolochiaefolia, and S. ornata from Mexico and Latin America; and S. glabra from China. Sarsaparilla vine should not be confused with the large sasparilla and sassafras trees (the root and bark of which were once used to flavor root beer). Sarsaparilla has been used as an ingredient in root beer and other beverages for its foaming properties—not for its flavoring properties.

Sarsaparilla contains the plant steroids sarsasapogenin, smilagenin, sitosterol, stigmasterol, and pollinastanol; and the saponins sarsasaponin, smilasaponin, sarsaparilloside, and sitosterol glucoside, among others. The majority of sarsaparilla's pharmacological properties and actions have been attributed to these steroids and saponins. The saponins have been reported to facilitate the body's absorption of other drugs and phytochemicals, which accounts for its history of use in herbal formulas as an agent for bioavailability and to enhancement the power and effect of other herbs.

Saponins and plant steroids found in many species of plants (including sarsaparilla) can be synthesized into human steroids such as estrogen and testosterone. This synthesis has never been documented to occur in the human body - only in the laboratory. Yet plant steroids and their actions in the human body have been a subject of much interest, sketchy research and, unfortunately, disinformation - mainly for marketing purposes. Sarsaparilla has been marketed (fraudulently) to contain testosterone and/or other anabolic steroids. While it is a rich source of natural plant steroids and saponins, it never has been proven to have any anabolic effects, nor has testosterone been found in sarsaparilla or any other plant source thus far.

Flavonoids in sarsaparilla have been documented to have immune modulation and liver protective activities. A U.S. patent was awarded in 2003 describing these flavonoids to be effective in treating autoimmune diseases and inflammatory reactions through their immunomodulating effects. Sarsasapogenin and smilagenin were subjects of a 2001 U.S. patent which reported that these Smilax steroids had the ability to treat senile dementia, cognitive dysfunction, and Alzheimer's disease. These studies, however, have not been published in any peer-reviewed journals - only in the context of the patent, thus far.

Clinical research has validated the traditional use of sarsaparilla for skin conditions such as psoriasis, eczema, acne, and leprosy. In 1942, it was reported in the New England Journal of Medicine to improve the condition of psoriasis dramatically. There the results of a clinical study with 92 patients was detailed which reported that it improved psoriasis lesions in 62% of cases and completely cleared lesions in 18% of cases. One of the possible mechanisms of action in psoriasis is sarsaparilla's blood cleansing properties. Individuals with psoriasis have been found to have high levels of endotoxins circulating in the bloodstream (endotoxins are cell wall fragments of normal gut bacteria). Sarsaponin, one of sarsaparilla's main steriods, was found to bind to these endotoxins and remove them, thus improving psoriasis.

This endotoxin-binding action is probably why the root has been used for centuries as a "blood purifier." Other health conditions associated with high endotoxin levels include eczema, arthritis, and ulcerative colitis. Sarsaparilla's effective use in the treatment of leprosy has been documented in a 1959 human trial. The effectiveness of sarsaparilla in the treatment of adolescent acne caused by excessive androgens has received some experimental support as well.

A 2001 U.S. patent was filed on sarsaparilla (Smilax china) for psoriasis and respiratory diseases. This patent cited clinical observations and studies with children and human adults with Psoriasis vulgaris, pustular psoriasis, erythroderma psoriaticum lesions, and associated itching-reporting marked clinical improvements with dosages of 3-6 g daily. It also reported that, upon discontinuation of sarsaparilla after only two months of treatment, there was further gradual remission of lesions and no side effects. In addition, this patent indicated sarsaparilla was shown to be a preventative and therapeutic agent for respiratory and allergic diseases such as acute bronchitis, bronchial asthma, asthmatic bronchitis, and chronic bronchitis. Again, these studies and observations reported in the patent have yet to be published in any peer-reviewed journals.

Sarsaparilla has long been used in the treatment of syphilis. Clinical observations in China demonstrated that sarsaparilla was effective (according to blood tests) in about 90% of acute and 50% of chronic cases. In the 1950s the antibiotic properties of sarsaparilla were documented; other studies documented its antifungal and antimycobacterial activities. Its anti-inflammatory activity has been demonstrated in several in vitro and in vivo studies, using different laboratory-induced models of arthritis and inflammation. One of these studies attributes the beneficial effect for arthritis to sarsaparilla's immune modulatory action. Sarsaparilla also has demonstrated liver protective effects in rats, with researchers concluding that it is able to prevent immune-mediated liver injury. Improvement of appetite and digestion has been noted with sarsaparilla, as well as its diuretic actions in humans. The root has been reported to have stimulatory activity on the kidneys in humans and, in chronic nephritis, it was shown to increase the urinary excretion of uric acid.

Sarsaparilla root has been used for centuries by the indigenous peoples of Central and South America for sexual impotence, rheumatism, skin ailments, and as a general tonic for physical weakness. Sarsaparilla root also was used as a general tonic by indigenous tribes in South America, where New World traders found it and introduced it into European medicine in the 1400s.

Sarsaparilla is becoming more widely available in health food stores, with a variety of tablets, capsules, and tincture products sold today.. In naturopathic and herbal medicine, it is used mostly in combination with other herbs for its tonic, detoxifying, blood purifying, and lymph-cleansing properties. In retail stores and products, it can be found as an ingredient in various herbal remedies made for skin disorders, libido enhancement, hormone balancing, and sports nutrition formulas. It's also commonly used in herbal preparations as a synergist or bioavailability aid - as it is thought that the saponins in sarsaparilla root increase the absorption of other chemicals in the gut. No known toxicity or side-effects have been documented for sarsaparilla; however, ingestion of large dosages of saponins may cause gastrointestinal irritation.

Following- up, a brief summary of worldwide ethnomedical uses of sarasaparilla.

Region	Uses
Argentina	for rheumatism, and to increase perspiration and libido
Brazil	for acne, anorexia, arthritis, blood purification, digestive disorders, eczema, fever, gallstones, gout, hives, kidney problems, kidney stones, impotence, leprosy, muscle weakness, psoriasis, rheumatism, skin disorders, sterility, syphilis, ulcers, urinary insufficiency, venereal diseases, and as an aphrodisiac, laxative, and to increase perspiration
China	for abscesses, arthritis, boils, cystitis, diarrhea, digestive disorders, dysentery, enteritis, fever, malaria, mercury poisoning, rheumatism, rheumatoid arthritis, skin problems, sores, syphilis, urinary insufficiency, and as an aphrodisiac and tonic
England	for abscesses, anorexia, antiseptic, blood cleansing, cancer, dysentery, eczema, fatigue, gout, immune enhancement, impotence, infections, inflammation, itching, leprosy, mercury poisoning, muscle weakness, PMS, psoriasis, rheumatism, rheumatoid arthritis, skin problems, syphilis, tonic, venereal diseases and as an aphrodisiac, antiseptic, diuretic, and to increase perspiration
Europe	for arthritis, inflammation, kidney problems, psoriasis, rheumatism, skin problems, sweat promotion, urinary disorders, urinary insufficiency, venereal diseases
Latin America	for aches, acne, arthritis, colds, digestive disorders, fever, gout, impotence, pain, psoriasis, rheumatism, skin problems, sweat promotion, syphilis, venereal disease, weakness, and as an aphrodisiac and tonic
Mexico	for arthritis, blood purification, burns, cancer, digestive disorders, dyspepsia, eczema, fever, gonorrhea, inflammation, leprosy, nephritis, rash, rheumatism, scrofula, skin problems, syphilis, venereal disease, and to increase perspiration and urination
United States	for acne, arthritis, bladder problems, blood purification, burns, cancer, convalescence, coughs, diabetes, digestive disorders, eczema, eye infections, fatigue, fever, gonorrhea, gout, herpes, hives, hypertension, impotence, infertility, inflammation, itching, kidney problems, laxative, liver protection, pleurisy, PMS, psoriasis, rheumatism, scrofula, shingles, skin problems, stomach disorders, stress, sweat promotion, syphilis, tuberculosis, ulcers, ulcerative colitis, urinary disorders, urinary insufficiency, vaginal discharge, venereal disease, warts, wounds, and as an expectorant
Elsewhere	for abscesses, arthritis, asthma, boils, burns, cancer, colds, conjunctivitis, cystitis, dyspepsia, dysentery, eczema, edema, epilepsy, gonorrhea, gout, herpes, impotence, inflammation, intestinal gas, kidney problems, leprosy, lymph inflammation, malaria, menstrual disorders, psoriasis, rashes, stimulant, tonic, toothache, tumor, urogenital diseases, venereal disease, wounds, and as an aphrodisiac, stimulant, and tonic

 

SARSAPARILLA PLANT SUMMARY

Main Preparation Method:	capsules or decoction
Main Actions (in order):	blood cleanser, immunomodulator (selectively reduces overactive immune cells), antimutagenic (cellular protector), detoxifier, tonic (tones, balances, strengthens overall body functions)
Main Uses:	for psoriasis, dermatitis, leprosy, and other skin disorders as a blood purifier and general detoxification aid as a general tonic (tones, balances, strengthens), stimulant, and hormonal regulator for arthritis, rheumatism and autoimmune disorders which cause inflammation for syphilis and other sexually transmitted diseases
Properties/Actions Documented by Research:	anti-inflammatory, antibacterial, antifungal, antimutagenic (cellular protector), blood cleanser, detoxifier, diuretic, hepatoprotective (liver protector), immunomodulator (selectively reduces overactive immune cells), neuroprotective (protects brain cells)
Other Properties/Actions Documented by Traditional Use:	absorption aid, analgesic (pain-reliever), anticancerous, antioxidant, antirheumatic, antiseptic, aphrodisiac, diaphoretic (promotes sweating), digestive stimulant, febrifuge (reduces fever), stimulant, tonic (tones, balances, strengthens), wound healer
Traditional Preparation:	One-half to 1 cup of a standard root decoction 2-3 times daily. Alternatively, 1-2 grams of root powder in tablets or capsules twice daily or 2-3 ml of a standard tincture or fluid extract may be taken twice daily.
Contraindications:	Large doses may cause gastrointestinal upset.
Drug Interactions:	Sarsaparilla may increase the absorption of some drugs and compounds. Some report that it can increase the absorption of Digitalis glycosides while accelerating the elimination of hypnotic drugs.

WARNINGS: Information, statements and products on this website have not been evaluated by the FDA and are not intended to diagnose, mitigate, treat, cure, or prevent any disease or health condition. The natural properties of the botanicals are only referred to their common uses among folk and herbal traditions. Our products are not intended to diagnose, cure, or prevent any disease as well. It's not meant to give any suggestion of diagnosis or disease treatment. Please see a doctor when needed.