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Brain Support(cervello)

Brain Support(cervello)
120 Caps (650mg per cap.)
29.90€
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Brain Support è una miscela di 10 piante della foresta amazzonica che venivano tradizionalmente usate per il supporto della memoria e delle funzioni cerebrali, oltre che per mal di testa, come tonici ed antiossidanti del sistema nervoso centrale.


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Ingredienti: Miscela al 100% naturale di samambaia e calaguala, tamamuri, catuaba, muira puama, cat's claw, suma, guaranà, nettle, sarsaparilla

Uso suggerito: Come integratore alimentare. Prendere 2 capsule 2- 3 volte al giorno.

Controindicazioni: Non usare durante la gravidanza o l'allattamento.

Precauzioni: Non superare la dose giornaliera raccomandata. Questo prodotto è un supplemento nutrizionale che non deve sostituire un’alimentazione varia ed equilibrata. Tenere lontano dalla portata dei bambini al di sotto dei 3 anni. Conservare al riparo dalla luce, da fonti di calore e dall’umidità. Come con ogni supplemento nutrizionale, consultare un medico prima di assumerlo durante la gravidanza, l’allattamento o nel caso di problemi di salute.


Bibliografia

Samambaia & Calaguala (Polypodium decumanum & Polypodium leucotomos)
Alvarez, X. A., et al. "Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics." Methods Find. Exp. Clin. Pharmacol. 2000; 22(7): 585-94.
Cacabelos, R., et al. "A pharmacogenomic approach to Alzheimer's disease." Acta Neurol. Scand. Suppl. 2000; 176: 12-19.
Alvarez, X. A., et al. "Anapsos improves learning and memory in rats with Beta-Amyloid (1-28) deposits in the hippocampus" Progress in Alzheimer's and Parkinson's Diseases, Ed. Fisher, A., Yoshida, M. and Hannin, I., Plenum Press, New York, 1998; pp. 699-703
Nikolov, R. "Alzheimer's disease therapy - an update." Drug News Perspect. 1998 May; 11(4): 248-55.
Alvarez, X. A., et al. "Anapsos reverses interleukin-1 beta overexpression and behavioral deficits in nbM-lesioned rats." Methods Find. Exp. Clin. Pharmacol. 1997; 19(5): 299-309.
Fernandez-Novoa, L., et al. "Effects of Anapsos on the activity of the enzyme Cu-Zn-superoxide dismutase in an animal model of neuronal degeneration." Methods Find. Exp. Clin. Pharmacol. 1997; 19(2): 99-106.
Quintanilla A. E., et al. "Pharmaceutical composition of activity in the treatment of cognitive and/or neuroimmune dysfunctions." U.S. patent no. 5,601,829; 1997.

Tamamuri (Brosimum acutifolium)
Takashima, J., et al. “Mururins A-C, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity.” Planta Med. 2002; 68(7): 621-625.
Aksoy, E., et al. “Protein kinase C epsilon: A new target to control inflammation and immune-mediated disorders.” Int. J. Biochem. Cell Biol. 2004; 36(2): 183-8.
Stallings-Mann, M., et al. “A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells.” Cancer Res. 2006 Feb; 66(3):1767-74.
Cohen, E. E., et al. “Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.” Cancer Res. 2006 Jun; 66(12): 6296-303.

Catuaba (Erythroxylum catuaba)
Campos, M., et al. “Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms.” Psychopharmacology. 2005 Oct; 182(1): 45-53.
Barbosa, N. R., et al. “Inhibition of platelet phospholipase A2 activity by catuaba extract suggests anti-inflammatory properties.” Phytother. Res. 2004; 18(11): 942-4.
Vaz, Z. R., et al. “Analgesic effect of the herbal medicine Catuaba in thermal and chemical models of nociception in mice.” Phytother. Res. 1997; 11(2): 101–6.

Muira puama (Ptychopetalum olacoides)
da Silva, A. L., et al. "Promnesic effects of Ptychopetalum olacoides in aversive and non-aversive learning paradigms." J. Ethnopharmacol. 2007 Feb; 109(3): 449-457.
da Silva, A. L., et al. "Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice." J. Ethnopharmacol. 2004 Dec; 95(2-3): 199-203.
Siqueira, I. R., et al. "Neuroprotective effects of Ptychopetalum olacoides Bentham (Olacaceae) on oxygen and glucose deprivation induced damage in rat hippocampal slices." Life Sci. 2004 Aug; 75(15): 1897-906.
Siqueira, I. R., et al. "Ptychopetalum olacoides, a traditional Amazonian "nerve tonic," possesses anticholinesterase activity." Pharmacol. Biochem. Behav. 2003 Jun; 75(3): 645-50.
da Silva, A. L., et al. "Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama)." Phytother. Res. 2002; 16(3): 223-6.
Siqueira, I. R., et al. "Psychopharamcological properties of Ptychopetalum olacoides Bentham (Olacaceae)." Pharmaceutical Biol. 1998; 36(5): 327–34.
Forgacs, P., et al. "Phytochemical and biological activity studies on 18 plants from French Guyana." Plant Med. Phytother. 1983; 17(1): 22–32.

Cat’s Claw (Uncaria tomentosa)
Jurgensen, S., et al. “Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.” Pharmacol. Biochem. Behav. 2005 Jul; 81(3): 466-77.
Kang, T. H., et al. “Pteropodine and isopteropodine positively modulate the function of rat uscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte.” Eur. J. Pharmacol. 2002 ay; 444(1-2): 39-45.
Mohamed, A. F., et al. “ Effects of Uncaria tomentosa total alkaloid and its components on xperimental amnesia in mice: elucidation using the passive avoidance test.” J. Pharm. Pharmacol. 001; 52(12): 1553–61.
Roth, B. L., et al. “Insights into the structure and function of 5-HT(2) family serotonin receptors eveal novel strategies for therapeutic target development.” Expert Opin. Ther. Targets 2001 Dec; (6): 685-695.
Castillo, G., et al. “Pharmaceutical compositions containing Uncaria tomentosa extract for treating Alzheimer's disease and other amyloidoses." Patent-Pct. Int. Paol. 1998; 00 33,659: 67pp.
Pilarski, R., et al. “Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC.” J. Ethnopharmacol. 2006 Mar; 104(1-2): 18-23.

Suma (Pfaffia paniculata)
Marques, L. C., et al. "Psychopharmacological assessment of Pfaffia glomerata roots (extract BNT-08) in rodents." Phytother. Res. 2004 Jul; 18(7): 566-72.
de-Paris, F., et al. "Psychopharmacological screening of Pfaffia glomerata Spreng. (Amarathanceae) in rodents." J. Ethnopharmacol. 2000 Nov; 73(1-2): 261-9.
Mendes, F. R., et al. "Brazilian plants as possible adaptogens: An ethnopharmacological survey of books edited in Brazil." J. Ethnopharmacol. 2006 Sep 1;
Mazzanti, G., et al. "Analgesic and anti-inflammatory action of Pfaffia paniculata (Martius) Kuntze." Phytother. Res. 1994; 8(7): 413-16.
Mazzanti, G., et al. "Anti-inflammatory activity of Pfaffia paniculata (Martius) Kuntze and Pfaffia stenophylla (Sprengel) Stuchl." Pharmacol. Res. 1993; 27(1): 91–92.
de Oliveira, F. G., et al. "Contribution to the pharmacognostic study of Brazilian ginseng Pfaffia paniculata." An. Farm. Quim. 1980; 20(1–2): 277–361.

Guarana (Paullina cupana)
Haskell, C. F., et al. "A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guarana in humans." J. Psychopharmacol. 2007; 21(1): 65-70.
Kennedy, D. O., et al. “Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: Comparison and interaction with Panax ginseng.” Pharmacol. Biochem. Behav. 2004 Nov; 79(3): 401-11.
Espinola, E. B., et al. ”Pharmacological activity of Guarana (Paullinia cupana Mart.) in laboratory animals.” J. Ethnopharmacol. 1997 Feb; 55(3):223-9.
Galduróz, J. C., et al. “The effects of long-term administration of guaraná on the cognition of normal, elderly volunteers.” Rev. Paul. Med. 1996; 114(1): 1073–78.
Benoni, H., et al. “Studies on the essential oil from guaraná.” Z. Lebensm. Unters. Forsch. 1996; 203(1): 95–8.
Galduróz, J. C., et al. “Acute effects of the Paulinia cupana, ‘guaraná,’ on the cognition of normal volunteers.” Rev. Paul. Med. 1994; 112(3): 607–11.

Nettle (Urtica dioica)
Toldy, A., et al. “The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain.Brain Res. Bull. 2005 May 30; 65(6): 487-93.
Barneoud, P., et al. “Brain neocortex immunomodulation in rats.” Brain Res. 1988 Dec; 474(2): 394-8.
Rau, O., et al. “Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor.” Pharmazie. 2006; 61(11):952-6.
Kanter, M., et al. “Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats.” World J. Gastroenterol. 2005; 11(42): 6684-8.
Gullcin, I., et al. “Purification and characterization of polyphenol oxidase from nettle (Urtica dioica L.) and inhibitory effects of some chemicals on enzyme activity.” J. Enzyme Inhib. Med. Chem. 2005 Jun; 20(3): 297-302.
Gullcin, I., et al. “Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.).” J. Ethnopharmacol. 2004 Feb; 90(2-3): 205-15.

Sarsaparilla (Smilax sp)
Jeon, S. Y., et al. "Beta-secretase (BACE1)-inhibiting stilbenoids from Smilax Rhizoma." Phytomedicine. 2006 Nov 2
Ban, J. Y., et al. "Catechin and epicatechin from Smilacis chinae rhizome protect cultured rat cortical neurons against amyloid beta protein (25-35)-induced neurotoxicity through inhibition of cytosolic calcium elevation." Life Sci. 2006 Nov; 79(24) :2251-9.
Ren, L. X., et al. "Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae)." Biol. Pharm. Bull. 2006 Nov; 29(11): 2304-6.
Ban, J. Y., et al. "Protection of amyloid beta protein (25-35)-induced neurotoxicity by methanol extract of Smilacis chinae rhizome in cultured rat cortical neurons." J. Ethnopharmacol. 2006 Jun; 106(2): 230-7.
Barraclough , P., et al. "5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia." United States Patent 7,138,427: November 21, 2006.
Hu, Y., et al. "A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models." Brain Res. 2005 Oct; 1060(1-2): 26-39.
Xia, Z. et al. Steroidal sapogenins and their derivatives for treating Alzheimer's disease." United States Patent 6,812,213; November 2, 2004.


















AVVERTENZA: Le informazioni fornite in queste pagine hanno solo scopo informativo e sono tratte da pubblicazioni internazionali. Le proprietà naturali delle erbe sono unicamente da riferire alle comuni utilizzazioni nella tradizione popolare ed erboristica. I nostri prodotti non si propongono di diagnosticare, trattare, curare o prevenire alcuna malattia. Non si intende fornire suggerimenti per diagnosi o trattamenti di malattie. In caso di necessità consultare un medico.