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A-P *HEF

A-P *HEF
120 caps. (650mg)
29.90€
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A-P è una formulazione sinergica di 10 piante della foresta pluviale tradizionalmente usate in Sud America come rimedi popolari per infezioni da parassiti e amebe.


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Ingredienti: 100% pura miscela di amargo, simarouba, boldo, fedegoso, carqueja, quinine, erva tostão, epazote, anamu, e graviola. Non sono stati usati additivi, riempitivi o conservanti.

Uso suggerito: come integratore alimentare. Assumere 2-3 capsule 2 volte al giorno ai pasti (a seconda del peso corporeo)

Controindicazioni: Non usare durante la gravidanza o l'allattamento.

Interazioni con farmaci: Nessuna segnalata.

Altre informazioni pratiche:
  • Numerose piante contenute nella miscela hanno delle documentate proprietà ipotensive. Gli individui che soffrono di bassa pressione sanguigna dovrebbero pertanto controllarsi più attentamente a causa di questo possibile effetto.
  • É stato osservato che la formulazione è più efficace se assunta per un minimo di 40 giorni consecutivi.
  • Non eccedere la dose di 9 capsule al giorno. Dosi maggiori di quelle suggerite potrebbero causare crampi di stomaco.



Bibliografia

Amargo (Quassia amara)
Bertani, S., et al. "Quassia amara L. (Simaroubaceae) leaf tea: Effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation." J. Ethnopharmacol. 2006 Nov 6;
Bertani, S., et al. "Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)." J. Ethnopharmacol. 2006 Nov 3;108(1):155-7.
Vigneron, M., et al. “Antimalarial remedies in French Guiana: a knowledge attitudes and practices study.” J. Ethnopharmacol. 2005 Apr; 98(3): 351-60.
Bertani, S., et al. “Evaluation of French Guiana traditional antimalarial remedies.” J. Ethnopharmacol. 2005 Apr; 98(1-2): 45-54.
Ajaiyeoba, E. O., et al. "In vivo antimalarial activities of Quassia amara and Quassia undulata plant extracts in mice." J. Ethnopharmacol. 1999; 67(3): 321–25.
O'Neill, M. J., et al. "Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids." Antimicrob. Agents Chemother. 1986; 30(1): 101–4.
Trager, W., et al. "Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro." Am. J. Trop. Med. Hyg. 1981; 30(3): 531–37.
Garcia Gonzalez, M., et al. "Pharmacologic activity of the aqueous wood extract from Quassia amara (Simarubaceae) on albino rats and mice." Rev. Biol. Trop. 1997; 44–45: 47–50.
Ninci, M. E. "Prophylaxis and treatment of pediculosis [lice] with Quassia amarga." Rev. Fac. Cien. Med. Univ. Nac. Cordoba 1991; 49(2): 27–31.
Wright, C. W., et al. "Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids." Antimicrob. Agents Chemother. 1988; 32(11): 1725-9.

Simarouba (Simarouba amara)
Francois, G., et al. ”Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships.” Int. J. Parasitol. 1998; 28(4): 635-40.
Franssen, F. F., et al. “In vivo and in vitro antiplasmodial activities of some plants traditionally used in Guatemala against malaria.” Antimicrob. Agents Chemother. 1997; 41(7): 1500–3.
Wright, C. W., et al. “Quassinoids exhibit greater selectivity against Plasmodium falciparum than against Entamoeba histoyltica, Giardia intestinalis or Toxoplasma gondii in vitro." J. Eukaryot. Microbiol. 1993; 40(3): 244–46.
Kirby, G. C., et al. “In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum.” Biochem. Pharmacol. 1989; 38(24): 4367–74.
O’Neill, M. J., et al. “Plants as sources of antimalarial drugs, Part 6. Activities of Simarouba amara fruits." J. Ethnopharmacol. 1988; 22(2): 183–90.
O’Neill, M. J., et al. “The activity of Simarouba amara against chloroquine-resistant Plasmodium falciparum in vitro." J. Pharm. Pharmacol. 1987; Suppl. 39: 80.
Monjour, I., et al. “Therapeutic trials of experimental murine malaria with the quassinoid, glaucarubinone.” C. R. Acad. Sci. Ill. 1987; 304(6): 129–32.
Trager, W., et al. “Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro." Am. J. Trp. Med. Hyg. 1981; 30(3): 531–37.
Duriez, R., et al. “Glaucarubin in the treatment of amebiasis." Presse Med. 1962; 70: 1291.
Spencer, C. F., et al. “Survey of plants for antimalarial activity.” Lloydia 1947; 10: 145–74.
Cuckler, A. C., et al. “Efficacy and toxicity of simaroubidin in experimental amoebiasis.” Fed. Proc. 1944; 8: 284.
Shepheard, S., et al. "Persistent carriers of Entameba histolytica." Lancet 1918: 501.

Boldo (Peumus boldus)
Okuyama, E., et al. “ Ascaridole as a pharmacologically active principle of "Paico," a medicinal Peruvian plant.” Chem. Pharm. Bull. 1993; 41(7): 1309-11.
Pollack, Y., et al. “The effect of ascaridole on the in vitro development of Plasmodium falciparum.” Parasitol. Res. 1990; 76(7): 570-2.
Morello, A., et al. “Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi.” Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol. 1994; 107(3): 367-71.
Gotteland, M., et al. “Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers.” Rev. Med. Chil. 1995; 123(8): 955-60.
Peters, W., et al. "The chemotherapy of rodent malaria. XLVIII. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 1: Studies leading to the development of novel cis-fused cyclopenteno derivatives." Ann. Trop. Med. Parasitol. 1993 Feb; 87(1): 1-7.

Fedegoso (Cassia occidentalis)
Schmeda-Hirschmann, G., et al. “A screening method for natural products on triatomine bugs.” Phytother. Res. 1989; 6(2): 68–7
Tona, L., et al. “In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo.” J. Ethnopharmacol. 2004 Jul; 93(1): 27-32.
Tona, L., et al. “In-vivo antimalarial activity of Cassia occidentalis, Morinda morindoides and Phyllanthus niruri.” Ann. Trop. Med. Parasitol. 2001; 95(1): 47–57.
Tona, L., et al. “Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo.” J. Ethnopharmacol. 1999 Dec 15; 68(1-3): 193-203.
Gasquet, M., et al. "Evaluation in vitro and in vivo of a traditional antimalarial, ‘Malarial 5.'" Fitoterapia. 1993; 64(5): 423.

Carqueja (Baccharis genistelloides, trimera)
Sosa, M. E., et al. “Insect antifeedant activity of clerodane diterpenoids.” J. Nat. Prod. 1994; 57(9): 1262–
Herz, W., et al. “New ent-clerodane-type diterpenoids from Baccharis trimera.” J. Org. Chem. 1977 Nov 25; (24): 42.
Gonzales, E., et al. “Gastric cytoprotection of Bolivian medicinal plants.” J. Ethnopharmacol. 2000; 70(3): 329–33.
Melo, S. F., et al. “Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli.” Mutat. Res. 2001 Sep 20; 496(1-2): 33–8.

Quinine (Cinchona succirubra)
Bertani, S., et al. "Evaluation of French Guiana traditional antimalarial remedies." J. Ethnopharmacol. 2005 Apr; 98(1-2): 45-54.
Pukrittayakamee, S., et al. "Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria." Antimicrob. Agents Chemother. 2003; 47(11): 3458-63.
Warhurst, D. C., et al. “The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids. Malar. J. 2003 Sep 01; 2(1):26.
Pussard, E., et al. "Quinine distribution in mice with Plasmodium berghei malaria." Eur. J. Drug Metab. Pharmacokinet. 2003 Jan-Mar; 28(1): 11-20.
Nakajima, Y. "Antiprotozoal drugs." Nippon Rinsho. 2003 Feb; 61 Suppl 2: 774-9.
Vieira, J. L., et al. "Drug monitoring of quinine in men with nonsevere falciparum malaria: study in the Amazon region of Brazil." Ther. Drug Monit. 2001 Dec; 23(6): 612-5.
Tagboto, S., et al. "Antiparasitic properties of medicinal plants and other naturally occurring products." Adv. Parasitol. 2001; 50: 199-295.
Aviado, D. M., et al. "Antimalarial and antiarrhythmic activity of plant extracts." Medicina Experimentalis—International Journal of Experimental Medicine 1969; 19(20), 79–94.

Erva Tostão (Boerhaavia diffusa)
Hilou, A., et al. "In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in mice." J. Ethnopharmacol. 2006 Jan; 103(2): 236-40.
Sohni, Y., et al. “The antiamoebic effect of a crude drug formulation of herbal extracts against Entamoeba histolytica in vitro and in vivo.” J. Ethnopharmacol. 1995; 45 1: 43–52.
Sohni, Y. R., et al. “Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies.” J. Ethnopharmacol. 1996 Nov; 54(2-3): 119–24.
Vijayalakshimi, K., et al. “Nematicidal properties of some indigenous plant materials against second stage juveniles of Meloidogyne incognita (koffoid and white) chitwood.” Indian J. Entomol. 1979; 4(4): 326–331.
Borrelli F, et al. “Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motility.” Planta Med. 2005; 71(10): 928-32.

Epazote (Chenopodium ambrosioides)
Monzote, L., et al. "Activity of the essential oil from Chenopodium ambrosioides grown in Cuba against Leishmania amazonensis." Chemotherapy. 2006; 52(3): 130-6.
Chiasson, H., et al. “Acaricidal properties of a Chenopodium-based botanical.” J. Econ. Entomol. 2004 Aug; 97(4): 1373-7.
Lopez de Guimaraes, D., et al. “Ascariasis: comparison of the therapeutic efficacy between paico and albendazole in children from Huaraz.” Rev. Gastroenterol 2001; 21(3): 212-9.
Giove Nakazawa, R. A. “Traditional medicine in the treatment of enteroparasitosis.” Rev. Gastroenterol.1996; 16(3): 197-202.
Kliks, M. M., et al. “Studies on the traditional herbal anthelmintic Chenopodium ambrosioides L.: Ethnopharmacological evaluation and clinical field trials.” Soc. Sci. Med. 1985; 21(8): 879-86.
Quinlan, M. B., et al. “Ethnophysiology and herbal treatments of intestinal worms in Dominica, West Indies.” J. Ethnopharmacol. 2002; 80(1): 75-83.
Kiuchi, F., et al. “Monoterpene hydroperoxides with trypanocidal activity from Chenopodium ambrosioides.” J. Nat. Prod. 2002; 65(4): 509-12.

Anamu (Petiveria alliacea)
Caceres, A., et al. “Plants used in Guatemala for the treatment of protozoal infections. I. Screening of activity to bacteria, fungi and American trypanosomes of 13 native plants.” J. Ethnopharmacol. 1998 Oct; 62(3): 195–202.
Berger I., et al. “Plants used in Guatemala for the treatment of protozoal infections: II. Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cruzi.” J. Ethnopharmacol. 1998 Sep; 62(2): 107-15.
Kim, S., et al. “Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria alliacea L.” J. Ethnopharmacol. 2006 Mar; 104(1-2): 188-92.

Graviola (Annona muricata)
Bories, C., et al. "Antiparasitic activity of Annona muricata and Annona cherimolia seeds." Planta Med. 1991; 57(5): 434-36.
Mesquita, M. L., et al. "Antileishmanial and trypanocidal activity of Brazilian Cerrado plants." Mem. Inst. Oswaldo Cruz. 2005 Nov; 100(7): 783-7.
Githiori, J. B., et al. "Evaluation of anthelmintic properties of some plants used as livestock dewormers against Haemonchus contortus infections in sheep." Parasitology. 2004 Aug; 129(Pt 2): 245-53.
Jaramillo, M. C., et al. "Cytotoxicity and antileishmanial activity of Annona muricata pericarp." Fitoterapia. 2000 Apr; 71(2): 183-6.
Heinrich, M., et al. "Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico)." J. Ethnopharmacol. 1992; (36)1: 81-5.
Antoun, M. D., et al. "Screening of the flora of Puerto Rico for potential antimalarial bioactives." Int. J. Pharmacog. 1993; 31(4): 255-58.
Tattersfield, F., et al. "The insecticidal properties of certain species of Annona and an Indian strain of Mundulea sericea (Supli)." Ann. Appl. Biol. 1940; 27: 262-73.





AVVERTENZA: Le informazioni fornite in queste pagine hanno solo scopo informativo e sono tratte da pubblicazioni internazionali. Le proprietà naturali delle erbe sono unicamente da riferire alle comuni utilizzazioni nella tradizione popolare ed erboristica. I nostri prodotti non si propongono di diagnosticare, trattare, curare o prevenire alcuna malattia. Non si intende fornire suggerimenti per diagnosi o trattamenti di malattie. In caso di necessità consultare un medico.